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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Artesunate, Fluorouracil
Phytochemical Name Artesunate (PubChem CID: 6917864 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Fluorouracil
Adverse Reactions Application site erythema, application site pruritus. This was inferred hot nature anticancer drug.
Recommendations Cold: Pueraria thomsonii; Bupleurum scorzonerifolium; Pueraria thomsonii; Pueraria edulis
Reference Traditional Chinese medicine characteristics of chemotherapy regimens in advanced gastrointestinal malignant tumours[J]. Global Traditional Chinese Medicine,2023,16(8):1596-1599. DOI:10.3969/j.issn.1674-1749.2023.08.019.　　ref_link
Combination Pair ID: 1004
Ref_1
Pair Name Artesunate, Fluorouracil
Disease Info [ICD-11: 2B91.Z] Colorectal cancer Investigative
Biological Phenomena Induction-->Cell senescence
Gene Regulation Down-regulation Expression TP53 hsa7157
Down-regulation Expression CDKN2A hsa1029
Down-regulation Expression CDKN1A hsa1026
Down-regulation Phosphorylation PRKAA1 hsa5562
Down-regulation Phosphorylation MTOR hsa2475
Down-regulation Phosphorylation RELA hsa5970
Down-regulation Phosphorylation MAPK14 hsa1432
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
HIEC-6 Healthy Homo sapiens (Human) CVCL_6C21
In Vivo Model HCT116 cells (1×10⁷) were subcutaneously inoculated into the left thigh dorsal region of nude mice, and tumor size was measured every 2 days for xenograft model establishment.
Result Our findings point to the crucial treatment effect of Arte on inflammation, intestinal cell senescence, and CRC cell proliferation and offer a new option for CRC treatment.
03. Reference
No. Title Href
1 Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity. Discov Oncol. 2023 Jul 27;14(1):139. doi: 10.1007/s12672-023-00747-7. Click
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